Incidence of BK Virus Nephropathy (BKVN) in Renal Transplant Recipients
نویسندگان
چکیده
BACKGROUND BK virus nephropathy (BKVN) is one of the complications of renal transplantation that causes graft loss in renal transplant recipients. OBJECTIVE To determine the incidence of BKVN after renal transplantation in Hasheminejad Hospital, Tehran, Iran. METHODS In this analytical cross-sectional study, we evaluated 31 consecutive kidney transplant recipients (21 men and 10 women) for BK and JC viral infections and BKVN during one year after transplantation, Urine of patients was tested for the presence of decoy cells and DNA of BK and JC virus by PCR. The serum load of BK and JC virus was assessed in patients 3, 6, 9, and 12 months after transplantation. Renal biopsy was performed in presence of allograft dysfunction or viral load >10(7) copies/mL. RESULTS The prevalences of decoy cells and BK and JC viral DNA in urine of patients were 16%, 29%, and 23%, respectively. BK or JC virus was found in 45% of the urine samples. During one year follow-up, no cases of BKVN was observed. CONCLUSION Despite a high rate of BK viral infection, no one with BKVN was observed in our kidney transplant recipients. Therefore, screening of all transplant recipients for BKVN is not recommended.
منابع مشابه
بررسی فراوانی نفروپاتی ناشی از ویروس BK در نمونه های بیوپسی
A Ghafari Moghaddam [1] , MD M Taghizadieh [2] , MD N Aghakhani [3] , MD N Ebrahimi [4] , MD E Rahimi [5] , MDM Ghasemi-rad [6] , MD, S Zafarshams pour [7] , MD Received: 29 April, 2007 Accepted: 29 Oct, 2008 Abstract Background &Aims: BK virus nephropathy is recognized as a cause of graft loss in renal transplant patients. The disorder may be related to the introduction of new, potent im...
متن کاملHigh-level viruria as a screening tool for BK virus nephropathy in renal transplant recipients
BACKGROUND Although early monitoring of BK virus infection in renal transplant patients has led to improved outcomes over the past decade, it remains unclear whether monitoring for viremia is the best screening tool for BK virus nephropathy (BKVN). METHODS We conducted a retrospective review of the medical records of 368 renal transplant recipients who had a minimum of 18 months of posttransp...
متن کاملOutcomes of renal transplant recipients with BK virus infection and BK virus surveillance in the Auckland region from 2006 to 2012
AIM To evaluate incidence, risk factors and treatment outcome of BK polyomavirus nephropathy (BKVN) in a cohort of renal transplant recipients in the Auckland region without a formal BK polyomavirus (BKV) surveillance programme. METHODS A cohort of 226 patients who received their renal transplants from 2006 to 2012 was retrospectively reviewed. RESULTS Seventy-six recipients (33.6%) had a B...
متن کاملBK Virus Associated Nephropathy, a Cause of Early Renal Allograft Dysfunction: A Single Centre Study.
BACKGROUND BK virus associated nephropathy (BKVN) is an important cause of early graft dysfunction in renal transplant recipients. The present study was carried out to determine the burden of BKVN in a single renal transplant centre in Australia. METHOD A retrospective analysis of de novo renal transplant recipients from 2010 to 2013 was performed to identify biopsy proven BKVN. Estimated glo...
متن کاملA Preliminary Study Into the Significance of Intrarenal Reflux in BK Virus Nephropathy After Kidney Transplantation
BACKGROUND The BK virus typically colonizes the lower urinary tract and is the causative agent in BK virus nephropathy (BKVN), which can progress to allograft dysfunction and graft loss. Urinary reflux in kidney allografts is induced by vesicoureteral reflux or disturbances in intrarenal reflux (IRR), believed to be associated with BKVN. This study was designed to elucidate the relationship bet...
متن کامل